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The derailment of a train carrying a flammable, toxic gas near Knoxville, Tenn. on Thursday has forced the evacuation of roughly 5,000 people.

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Local news WSMV reported Thursday morning that a “frantic cleanup effort” was ongoing. The flames will be allowed to burn out.

According to a statement from the train company, CSX, the 57-car train departed from Cincinnati, Ohio, and was headed to Waycross, Ga., when a single car derailed around midnight in Maryville and caught fire.

Twenty-seven of the train cars were carrying acrylonitrile, which the Environmental Protection Agency classifies as a probable human carcinogen.

The Knoxville News Sentinel reports that authorities were requesting kits to treat cyanide poisoning, as cyanide is a byproduct of acrylonitrile burning.